The effects of calcium antagonists on anthrone skin tumor promotion and promoter-related effects in SENCAR mice.

Abstract

The present study investigated a possible role for Ca2+ in skin tumor promotion by anthrones. This was accomplished by testing the effects of two Ca2+ antagonists, verapamil and 3,4,5-trimethoxybenzoic acid 8-(diethylamino) octyl ester (TMB-8), on tumor promotion and promoter-related effects induced by the anthrone chrysarobin in SENCAR mice. Verapamil and TMB-8 both effectively inhibited epidermal ornithine decarboxylase (ODC) induction by a single application of chrysarobin. Both Ca2+ antagonists inhibited anthrone-induced skin edema and epidermal hyperplasia. Additionally, both verapamil and TMB-8 slightly inhibited (20-21% at the highest doses) tumor promotion with chrysarobin. Although the inhibition by both Ca2+ antagonists was not statistically significant (P > 0.05) in either case, the fact that both compounds produced a similar inhibition suggests that this effect may be biologically relevant. Collectively, the data suggest a possible role for Ca2+ in the process of skin tumor promotion by anthrones.

• Authors: M S Battalora, D A Johnston, J DiGiovanni
• Journal: Cancer letters (Cancer Lett) Vol. 98 Issue 1 Pg. 19-25 (Nov 27 1995) ISSN: 0304-3835 [Print] Ireland
• PMID: 8529201 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Anthracenes
• Calcium Channel Blockers
• Carcinogens
• Ornithine Decarboxylase Inhibitors
• Reactive Oxygen Species
• 9,10-Dimethyl-1,2-benzanthracene
• 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate
• chrysarobin
• Gallic Acid
• Verapamil
• Calcium

Topics

• 9,10-Dimethyl-1,2-benzanthracene
• Animals
• Anthracenes (toxicity)
• Calcium (antagonists & inhibitors, metabolism)
• Calcium Channel Blockers (pharmacology)
• Carcinogens (toxicity)
• Edema (enzymology)
• Enzyme Induction (drug effects)
• Female
• Gallic Acid (analogs & derivatives, pharmacology)
• Hyperplasia (enzymology)
• Mice
• Mice, Inbred SENCAR
• Ornithine Decarboxylase Inhibitors
• Papilloma (chemically induced, metabolism)
• Reactive Oxygen Species (metabolism)
• Skin (enzymology, pathology)
• Skin Neoplasms (chemically induced, metabolism)
• Statistics, Nonparametric
• Verapamil (pharmacology)