The antimalarial drug, Ro 42-1611 (arteflene), does not affect cytoadherence and cytokine-inducing properties of Plasmodium falciparum malaria parasites.

Abstract	The purpose of this study was to investigate the ability of the antimalarial drug, Ro 42-1611 to block parasite mediated cytokine induction in vitro as well as cytoadherence of infected erythrocytes to melanoma cells in vitro. The biological activity of Ro 42-1611 was confirmed as it blocked Plasmodium falciparum growth in cultures. Ro 42-1611, had no major effect on TNF, IL-alpha or IL-6 cytokine release from mononuclear cells stimulated with malaria antigens or lipopolysaccharide and it did not affect cell viability. Ro 42-1611 only slightly suppressed cytoadherence of infected erythrocytes to melanoma cells. The therapeutic effect of To 42-1611 appears to be confined to its parasite killing activity.
Authors	P H Jakobsen, T Staalsø, K Bendtzen, D Stürchler
Journal	Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ) (Trop Med Parasitol) Vol. 46 Issue 2 Pg. 88-92 (Jun 1995) ISSN: 0177-2392 [Print] Germany
PMID	8525291 (Publication Type: Comparative Study, Journal Article)
Chemical References	Antigens, Protozoan Antimalarials Artemisinins Bridged Bicyclo Compounds, Heterocyclic Cytokines Immunoglobulin G Interleukin-1 Interleukin-6 Lipopolysaccharides Styrenes Tumor Necrosis Factor-alpha arteflene Chloroquine Mefloquine
Topics	Adult Animals Antigens, Protozoan (pharmacology) Antimalarials (pharmacology) Artemisinins Bridged Bicyclo Compounds, Heterocyclic (pharmacology) Cell Adhesion (drug effects) Cell Survival (drug effects, physiology) Chloroquine (pharmacology) Cytokines (biosynthesis) Dose-Response Relationship, Drug Enzyme-Linked Immunosorbent Assay Erythrocytes (drug effects, parasitology) Humans Immunoglobulin G Interleukin-1 (biosynthesis) Interleukin-6 (biosynthesis) Lipopolysaccharides (pharmacology) Lymphocytes (cytology, immunology, parasitology) Malaria, Falciparum (blood, immunology) Mefloquine (pharmacology) Melanoma Plasmodium falciparum (drug effects, immunology, physiology) Styrenes (pharmacology) Tumor Cells, Cultured Tumor Necrosis Factor-alpha (biosynthesis)

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