[Pre S1 antigen in different forms of hepatitis B virus infection].

Abstract

Pre S1 antigen was measured using an ELISA technique in patients with different forms of hepatitis B virus infection. It was detected in 10 of 19 patients with acute hepatitis B (53%), 12 of 15 chronic hepatitis B virus carriers (80%), 9 of 11 patients with chronic hepatitis B (82%) and 3 of 4 patients with hepatoma and positive markers of hepatitis B virus infection. Pre S1 remained positive beyond 150 days in two patients with acute hepatitis that evolved to chronicity. Among subjects with chronic hepatitis B that received interferon, pre S1 antigen negativized only in the patient that had a complete response. Pre S1 detection is an index of hepatitis B virus replication and its persistence determines chronicity. Its negativization after antiviral therapy should have a predictive value.

• Authors: J Brahm, C Hurtado, S Elgueta, C Fuentes, A Velásquez
• Journal: Revista medica de Chile (Rev Med Chil) Vol. 123 Issue 5 Pg. 567-70 (May 1995) ISSN: 0034-9887 [Print] Chile
• Vernacular Title: Antígeno Pre S1 en diferentes formas de infección con el virus de la hepatitis B.
• PMID: 8525202 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Hepatitis B Antigens

Topics

• Acute Disease
• Biomarkers
• Chronic Disease
• Enzyme-Linked Immunosorbent Assay
• Hepatitis B (immunology)
• Hepatitis B Antigens (analysis)
• Hepatitis B virus (genetics, immunology)
• Humans
• Virus Replication