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Mutagenicity and clastogenicity of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in L5178Y/TK+/(-)-3.7.2C mouse lymphoma cells.

Abstract
3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) was tested without exogenous activation in L5178Y/TK+/(-)-3.7.2C mouse lymphoma cells for mutation at the thymidine kinase locus and for clastogenicity. At a concentration of 0.75 micrograms/ml, the induced mutant frequency was 1027 per 10(6) survivors (survival = 11%). A concentration-related increase of large and small colony mutants was observed, but the majority of the MX induced mutants formed small colonies, consistent with the positive clastogenic response that was observed. MX primarily induced chromatid breaks and rearrangements (30 chromatid and 4 chromosome aberrations per 100 cells) at the 0.75 microgram/ml dose. These studies indicate that MX induces a broad spectrum of genetic damage.
AuthorsK Harrington-Brock, C L Doerr, M M Moore
JournalMutation research (Mutat Res) Vol. 348 Issue 3 Pg. 105-10 (Nov 1995) ISSN: 0027-5107 [Print] Netherlands
PMID8524361 (Publication Type: Journal Article)
Chemical References
  • Furans
  • Mutagens
  • Water Pollutants
  • 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone
  • Thymidine Kinase
Topics
  • Animals
  • CHO Cells
  • Clone Cells
  • Cricetinae
  • Furans (toxicity)
  • Lymphoma
  • Mice
  • Mutagens (toxicity)
  • Thymidine Kinase (genetics, metabolism)
  • Tumor Cells, Cultured
  • Water Pollutants (toxicity)

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