Malaria therapy and prophylaxis with cotrifazid, a multiple complex combination consisting of rifampicin + isoniazid + sulfamethoxazole + trimethoprim.

Abstract	This report contains the first therapeutic results with the multiple combination rifampicin + isoniazid + sulfamethoxazole + trimethoprim in the treatment of malaria. Clinical symptoms declined rapidly and parasites were cleared from the erythrocytes. Tolerance was excellent. This fixed combination is outstandingly practicable, with few problems with compliance.
Authors	E Freerksen, E W Kanthumkumwa, A R Kholowa
Journal	Chemotherapy (Chemotherapy) 1995 Sep-Oct Vol. 41 Issue 5 Pg. 396-8 ISSN: 0009-3157 [Print] Switzerland
PMID	8521742 (Publication Type: Clinical Trial, Journal Article)
Chemical References	Drug Combinations cotrifazid Trimethoprim Sulfamethoxazole Isoniazid Rifampin
Topics	Adolescent Adult Aged Child Child, Preschool Drug Combinations Female Follow-Up Studies Humans Infant Isoniazid (therapeutic use) Malaria (drug therapy) Male Middle Aged Rifampin (therapeutic use) Sulfamethoxazole (therapeutic use) Trimethoprim (therapeutic use)

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