Serum creatine kinase isoenzymes in Duchenne muscular dystrophy.

Abstract

Creatine kinase isoenzymes in sera of 51 patients with Duchenne muscular dystrophy were separated on a micro-column of DEAE Sephadex A-50. MB isoenzyme was detected in the sera of 32 cases (63%). MB percentage of total creatine kinase activity correlated significantly with urinary creatine/creatinine ratio in the early stages of the disease. No close relationship between MB levels and ECG findings was observed. The origin of serum MB in Duchenne dystrophy is discussed.

• Authors: K Takahashi, K Shutta, B Matsuo, T Takai, H Takao, H Imura
• Journal: Clinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 75 Issue 3 Pg. 435-42 (Mar 15 1977) ISSN: 0009-8981 [Print] Netherlands
• PMID: 852132 (Publication Type: Journal Article)

Chemical References

• Isoenzymes
• Creatinine
• Creatine Kinase
• Creatine

Topics

• Adolescent
• Adult
• Child
• Creatine (urine)
• Creatine Kinase (blood, isolation & purification)
• Creatinine (urine)
• Electrocardiography
• Humans
• Isoenzymes (blood, isolation & purification)
• Muscular Dystrophies (enzymology, physiopathology)