In vitro and in vivo evaluations of Chinese traditional (kampo) medicines as anticalculus agents in the rat.

Abstract

Inhibitory effects of two Chinese traditional (Kampo) medicines, Shigyaku-san and Shikunshi-to, on the in vitro formation of calcium phosphate precipitates and the in vivo deposition of supragingival dental calculus were studied. Both had inhibitory effects on hydroxyapatite transformation and induction; effects of Shigyaku-san and Shikunshi-to were 1/100 and 1/400 of that of 1-hydroxyethylidene-1,1-bisphosphonate (HEBP). When used topically (in drinking water) for 4 weeks, 20-40 mg/ml of Shigyaku-san or Shikunshi-to reduced the formation of dental calculus by 40-60%, while 0.03% (w/v) HEBP decreased it by 70-98%. However, when these drugs were given by gastric intubation for 2 weeks, they were all ineffective, suggesting that the observed anticalculus effects were of topical rather than of systemic origin.

• Authors: S Hidaka, K Abe, S Y Liu
• Journal: Archives of oral biology (Arch Oral Biol) Vol. 38 Issue 4 Pg. 327-35 (Apr 1993) ISSN: 0003-9969 [Print] England
• PMID: 8517804 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Calcium Phosphates
• Chelating Agents
• Drugs, Chinese Herbal
• Hydroxyapatites
• Egtazic Acid
• Etidronic Acid

Topics

• Administration, Topical
• Analysis of Variance
• Animals
• Calcium Phosphates (metabolism)
• Chelating Agents
• Dental Calculus (prevention & control)
• Drugs, Chinese Herbal (administration & dosage, therapeutic use)
• Egtazic Acid (therapeutic use)
• Etidronic Acid (therapeutic use)
• Hydroxyapatites (metabolism)
• Male
• Rats
• Rats, Wistar