[Activity of the antioxidant system of rat liver in benzidine poisoning and administration of enomelanin].

Abstract

It has been shown that benzidine administered in vivo attenuates the protective effect of the antioxidant system manifested as a reduction of the total antioxidant activity of rat liver cytosol and decreasing activities of superoxide dismutase and catalase. Enomelanin promotes the reconstitution of the superoxide dismutase activity. The data obtained suggest that the toxic effect of benzidine may be due to disturbances in the antioxidant protective mechanisms of liver cells responsible for the control over the free radical processes occurring in those cells.

• Authors: E E Lomonosova, A T Pikulev, V P Kurchenko
• Journal: Biokhimiia (Moscow, Russia) (Biokhimiia) Vol. 58 Issue 4 Pg. 580-4 (Apr 1993) ISSN: 0320-9725 [Print] Russia (Federation)
• Vernacular Title: Aktivnost' antioksidantnoĭ sistemy pecheni krys pri benzidinovoĭ intoksikatsii i vvedenii énomelanina.
• PMID: 8507733 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antioxidants
• Benzidines
• Free Radicals
• Melanins
• enomelanin
• benzidine
• Catalase
• Superoxide Dismutase

Topics

• Animals
• Antioxidants (metabolism)
• Benzidines (poisoning)
• Catalase (metabolism)
• Free Radicals
• Liver (enzymology)
• Male
• Melanins (administration & dosage, therapeutic use)
• Poisoning (drug therapy)
• Rats
• Superoxide Dismutase (metabolism)