Abstract | OBJECTIVE: DESIGN: Retrospective (before 1985) and prospective (after 1985) follow-up of a group of French haemophiliacs. METHODS: We studied 144 seropositive patients with moderate or severe haemophilia A or B or von Willebrand's disease. Enzyme-linked immunosorbent assay was used to screen patient sera for total HIV antigen and core p24 antigen antibodies. All patients were typed for HLA A, B and C antigens in the same laboratory. Time of seroconversion was estimated to be the mid-point between the last seronegative test and the first seropositive test. AIDS-free survival curves were constructed using the Kaplan-Meier estimate and differences in survival analysed using the Mantel-Cox test. The Cox proportional hazards model was used to adjust for confounding variables. RESULTS: Median follow-up after seroconversion was 8.7 years (range, 3.5-10.7 years). By the end of the study, six HLA-B35-positive patients and 12 HLA-B35-negative patients had progressed to AIDS. Individuals with HLA-B35 showed a significantly faster rate of progression to AIDS over the follow-up period than HLA-B35-negative individuals (hazard ratio, 2.72; P = 0.037). After adjusting for type and severity of haemophilia, CD4 cell count at first seropositive test, age at seroconversion, and zidovudine treatment before AIDS, the hazard ratio was 2.74 (P = 0.045). CONCLUSION:
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Authors | T Sahmoud, Y Laurian, C Gazengel, Y Sultan, C Gautreau, D Costagliola |
Journal | AIDS (London, England)
(AIDS)
Vol. 7
Issue 4
Pg. 497-500
(Apr 1993)
ISSN: 0269-9370 [Print] England |
PMID | 8507416
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Acquired Immunodeficiency Syndrome
(complications, epidemiology, immunology)
- Adolescent
- Adult
- Aged
- Child
- Child, Preschool
- France
(epidemiology)
- HIV Seropositivity
- HIV-1
(immunology)
- HLA-B35 Antigen
- Hemophilia A
(complications, immunology)
- Humans
- Infant
- Male
- Middle Aged
- Risk Factors
- Time Factors
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