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Progression to AIDS in French haemophiliacs: association with HLA-B35.

AbstractOBJECTIVE:
To evaluate whether HLA-B35 influences progression to AIDS in HIV-seropositive subjects with haemophilia.
DESIGN:
Retrospective (before 1985) and prospective (after 1985) follow-up of a group of French haemophiliacs.
METHODS:
We studied 144 seropositive patients with moderate or severe haemophilia A or B or von Willebrand's disease. Enzyme-linked immunosorbent assay was used to screen patient sera for total HIV antigen and core p24 antigen antibodies. All patients were typed for HLA A, B and C antigens in the same laboratory. Time of seroconversion was estimated to be the mid-point between the last seronegative test and the first seropositive test. AIDS-free survival curves were constructed using the Kaplan-Meier estimate and differences in survival analysed using the Mantel-Cox test. The Cox proportional hazards model was used to adjust for confounding variables.
RESULTS:
Median follow-up after seroconversion was 8.7 years (range, 3.5-10.7 years). By the end of the study, six HLA-B35-positive patients and 12 HLA-B35-negative patients had progressed to AIDS. Individuals with HLA-B35 showed a significantly faster rate of progression to AIDS over the follow-up period than HLA-B35-negative individuals (hazard ratio, 2.72; P = 0.037). After adjusting for type and severity of haemophilia, CD4 cell count at first seropositive test, age at seroconversion, and zidovudine treatment before AIDS, the hazard ratio was 2.74 (P = 0.045).
CONCLUSION:
HLA-B35 is a risk factor for more rapid progression to AIDS in subjects with haemophilia.
AuthorsT Sahmoud, Y Laurian, C Gazengel, Y Sultan, C Gautreau, D Costagliola
JournalAIDS (London, England) (AIDS) Vol. 7 Issue 4 Pg. 497-500 (Apr 1993) ISSN: 0269-9370 [Print] England
PMID8507416 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • HLA-B35 Antigen
Topics
  • Acquired Immunodeficiency Syndrome (complications, epidemiology, immunology)
  • Adolescent
  • Adult
  • Aged
  • Child
  • Child, Preschool
  • France (epidemiology)
  • HIV Seropositivity
  • HIV-1 (immunology)
  • HLA-B35 Antigen
  • Hemophilia A (complications, immunology)
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Risk Factors
  • Time Factors

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