Expression of interleukin-2R alpha and interleukin-2R beta in Hodgkin's disease.

Abstract

Hodgkin and Reed-Sternberg cells, the putative malignant cells of Hodgkin's disease (HD), carry regularly the CD25 antigen that forms one chain of the interleukin-2 (IL-2) receptor (IL-2R alpha). To analyze the putative role of IL-2R expression in Hodgkin's disease, we have investigated the expression of both IL-2R alpha and IL-2R beta chains in HD-derived cell lines and in primary specimens from patients with HD. Expression of IL-2R alpha and IL-2R beta was detected in all HD-derived cell lines. In addition, soluble IL-2R alpha molecules were demonstrated in the supernatants of three of these cultured cell lines. In primary tissues, IL-2R alpha and IL-2R beta were seen in some but not all cases. Staining was detected in Hodgkin and Reed-Sternberg and in lymphoid cells. There was a remarkable difference in the pattern of expression, in that IL-2R alpha- but not IL-2R beta-positive cells from HD patients were clustered in frozen sections. We conclude from these data that IL-2R expression might be involved in the biology of HD.

• Authors: H Tesch, A Günther, H Abts, M Jücker, S Klein, G R Krueger, V Diehl
• Journal: The American journal of pathology (Am J Pathol) Vol. 142 Issue 6 Pg. 1714-20 (Jun 1993) ISSN: 0002-9440 [Print] United States
• PMID: 8506943 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal
• Receptors, Interleukin-2

Topics

• Adolescent
• Adult
• Aged
• Antibodies, Monoclonal
• Enzyme-Linked Immunosorbent Assay
• Female
• Fluorescent Antibody Technique
• Hodgkin Disease (metabolism, pathology)
• Humans
• Immunohistochemistry
• Male
• Middle Aged
• Receptors, Interleukin-2 (analysis, genetics)
• Reed-Sternberg Cells (metabolism, pathology, ultrastructure)
• Tumor Cells, Cultured