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Copper benzochlorin, a novel photosensitizer for photodynamic therapy: effects on a transplantable urothelial tumor.

Abstract
An iminium salt of octaethylbenzochlorin with copper in the aromatic ring, CDS1, was tested for its tumoricidal effects on the AY-27 N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide tumor line. CDS1 was found to be an effective photosensitizer in vivo when used in combination with either a xenon arc lamp or a pulsed alexandrite laser. Hemodynamically, CDS1 and light caused a rapid decrease in tumor blood flow. Skin photosensitization was found to be minimal when drug-injected mice were illuminated in a solar simulator.
AuthorsS H Selman, J A Hampton, A R Morgan, R W Keck, A D Balkany, D Skalkos
JournalPhotochemistry and photobiology (Photochem Photobiol) Vol. 57 Issue 4 Pg. 681-5 (Apr 1993) ISSN: 0031-8655 [Print] United States
PMID8506398 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Deuteroporphyrins
  • Imines
  • Photosensitizing Agents
  • copper benzochlorin
Topics
  • Animals
  • Deuteroporphyrins (therapeutic use, toxicity)
  • Imines (therapeutic use, toxicity)
  • Light
  • Male
  • Mice
  • Mice, Hairless
  • Molecular Structure
  • Photochemotherapy
  • Photosensitizing Agents (therapeutic use, toxicity)
  • Rats
  • Rats, Inbred F344
  • Skin (drug effects, pathology)
  • Urinary Bladder Neoplasms (chemically induced, drug therapy, pathology)

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