Abstract |
An iminium salt of octaethylbenzochlorin with copper in the aromatic ring, CDS1, was tested for its tumoricidal effects on the AY-27 N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide tumor line. CDS1 was found to be an effective photosensitizer in vivo when used in combination with either a xenon arc lamp or a pulsed alexandrite laser. Hemodynamically, CDS1 and light caused a rapid decrease in tumor blood flow. Skin photosensitization was found to be minimal when drug-injected mice were illuminated in a solar simulator.
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Authors | S H Selman, J A Hampton, A R Morgan, R W Keck, A D Balkany, D Skalkos |
Journal | Photochemistry and photobiology
(Photochem Photobiol)
Vol. 57
Issue 4
Pg. 681-5
(Apr 1993)
ISSN: 0031-8655 [Print] United States |
PMID | 8506398
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Deuteroporphyrins
- Imines
- Photosensitizing Agents
- copper benzochlorin
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Topics |
- Animals
- Deuteroporphyrins
(therapeutic use, toxicity)
- Imines
(therapeutic use, toxicity)
- Light
- Male
- Mice
- Mice, Hairless
- Molecular Structure
- Photochemotherapy
- Photosensitizing Agents
(therapeutic use, toxicity)
- Rats
- Rats, Inbred F344
- Skin
(drug effects, pathology)
- Urinary Bladder Neoplasms
(chemically induced, drug therapy, pathology)
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