Angiotensin blockade and the progression of renal damage in the spontaneously hypertensive rat.
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| Abstract |
The pathophysiological role of angiotensin II in the development of renal sclerosis was investigated in 5/6-nephrectomized, 12-week-old male spontaneously hypertensive rats. After 1 week of a control period, nephrectomized rats received one of the following treatments for 4 weeks: the selective nonpeptide angiotensin II type 1 receptor antagonist TCV-116 (1 mg/kg per day), the angiotensin converting enzyme inhibitor delapril (30 mg/kg per day), hydralazine (15 mg/kg per day), or vehicle. Urinary protein and albumin excretions and systolic blood pressure were determined every week. Rats with reduced renal mass treated with vehicle had a poor survival rate (30%). Although TCV-116, delapril, and hydralazine treatment significantly improved the survival rate for 4 weeks, hydralazine failed to improve proteinuria and albuminuria as well as the decline in renal function compared with delapril or TCV-116. Histological examination revealed that both TCV-116 and delapril protected glomeruli from sclerosis, whereas hydralazine did not improve histological findings (5%, 7%, and 30% of glomeruli were affected, respectively). These results indicate that angiotensin II plays a dominant role through its type 1 receptor in the pathogenesis of renal deterioration by hypertension.
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| Authors | K Kohara, H Mikami, N Okuda, J Higaki, T Ogihara |
| Journal | Hypertension (Dallas, Tex. : 1979) (Hypertension) Vol. 21 Issue 6 Pt 2 Pg. 975-9 (Jun 1993) ISSN: 0194-911X [Print] United States |
| PMID | 8505110 (Publication Type: Comparative Study, Journal Article) |
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