| Abstract | Inflammation was induced in the lateral prostate of castrated Wistar rats by exposure to a sc implant of estradiol-filled Silastic tubing, followed by the addition of a dihydrotestosterone implant to restore prostatic wet weight. The presence of inflammation was correlated with increased serum PRL, elevated pituitary weight, and a greater than 2-fold increase in the lateral prostate DNA concentration. The administration of bromocriptine (4 mg/kg.day) to these animals was effective in suppressing pituitary weight and hyperprolactinemia and mitigated the lateral prostate inflammatory response. Inflammation was restored in the bromocriptine-treated hormone-implanted rats by administering exogenous ovine PRL at a dose of 2 mg/kg twice a day. The results indicate that estradiol-induced inflammation in the rat lateral prostate is mediated at least in part by the release of PRL from the pituitary. |
| Authors | L Tangbanluekal, C L Robinette
(Affiliation: Department of Anatomy, Physiological Sciences, and Radiology, North Carolina State University College of Veterinary Medicine, Raleigh 27606.)
|
| Journal | Endocrinology
(Endocrinology)
Vol. 132
Issue 6
Pg. 2407-16
(Jun 1993)
ISSN: 0013-7227 UNITED STATES |
| PMID | 8504745
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
|
| Chemical References |
- Estradiol
- Dihydrotestosterone
- Prolactin
- DNA
|
| Topics |
- Animals
- DNA
(metabolism)
- Dihydrotestosterone
(metabolism)
- Estradiol
- Male
- Organ Size
- Osmolar Concentration
- Pituitary Gland
(pathology)
- Prolactin
(blood, physiology)
- Prostate
(metabolism)
- Prostatitis
(chemically induced, pathology)
- Rats
- Rats, Wistar
|
