In exploring the effect of treatment of supporting the body resistance on
chronic renal failure, a
chronic renal failure model of rat was created by gastroperfusion of
adenine and evaluation was made on the
therapeutic effect of Kidney Invigorating and
Lipid Reducing Decoction (KILRD). The mental state and
body weight of the treated group have recovered well with
polyuria and proteinurea improving, BUN and
Creatinine decreasing, which appeared to be superior to the naturally recovered group. Renal pathological examination showed that: although the renal parenchymal damage was not reversed but its compensation was satisfactory with compensatory
hypertrophy appearing in unaffected nephron. The dominant reaction in the affected area was polynucleomacrocytosis,
foreign body granulamatosis, and interstitial lymphocytic infiltration, the
fibrosis was inevident, while the above-mentioned condition in the naturally recovered group was relatively more serious, with
fibrosis being observed. It was indicated that KILRD could increase the compensatory capacity and immunity, promote
protein synthetization and improve renal function. The study on KILRD proved to be a significant conservative medical treatment for
chronic renal failure.