Striatal hypometabolism distinguishes striatonigral degeneration from Parkinson's disease.

Abstract

Regional and global metabolic rates for glucose were estimated using 18F-fluorodeoxyglucose and positron emission tomography in 10 patients with a clinical likelihood of striatonigral degeneration (2 men and 8 women; mean age, 61.8 +/- 6.9 years; mean disease duration, 4.7 +/- 2.2 years; mean Hoehn and Yahr score, 3.5 +/- 0.8). Measures of brain glucose metabolism in these patients were compared with those for 10 age-matched normal volunteers, 10 disease severity-matched patients with Parkinson's disease (PD), and 10 disease duration-matched patients with PD. Normalized glucose metabolism was significantly reduced in the caudate (p < 0.03) and putamen (p < 0.003) as compared with that in normal and PD control subjects, and discriminated patients with striatonigral degeneration from control subjects (p < 0.002). Putamenal hypometabolism in patients with striatonigral degeneration correlated significantly with quantitative ratings of motor disability (p < 0.02). These results suggest that quantitative 18F-fluorodeoxyglucose positron emission tomography techniques may be useful in supporting a diagnosis of striatonigral degeneration in life, and in objectively assessing disease severity and potential therapeutic interventions.

• Authors: D Eidelberg, S Takikawa, J R Moeller, V Dhawan, K Redington, T Chaly, W Robeson, J R Dahl, D Margouleff, E Fazzini
• Journal: Annals of neurology (Ann Neurol) Vol. 33 Issue 5 Pg. 518-27 (May 1993) ISSN: 0364-5134 [Print] United States
• PMID: 8498828 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Fluorine Radioisotopes
• Fluorodeoxyglucose F18
• Deoxyglucose
• Glucose

Topics

• Aged
• Brain (diagnostic imaging, metabolism)
• Corpus Striatum (diagnostic imaging, metabolism, pathology)
• Deoxyglucose (analogs & derivatives, metabolism)
• Female
• Fluorine Radioisotopes
• Fluorodeoxyglucose F18
• Glucose (metabolism)
• Humans
• Kinetics
• Male
• Middle Aged
• Organ Specificity
• Parkinson Disease (diagnostic imaging, metabolism, pathology)
• Reference Values
• Substantia Nigra (diagnostic imaging, metabolism, pathology)
• Tomography, Emission-Computed