A comparative study of cephradine, amoxycillin and phenoxymethylpenicillin in the treatment of acute dentoalveolar infection.

Abstract

A comparative double blind trial was undertaken of the efficacy of cephradine, amoxycillin and phenoxymethylpenicillin in the treatment of acute dentoalveolar abscesses. Patients were admitted to the trial with acute dentoalveolar abscesses with systemic involvement and assessments were made of pain, swelling, temperature and lymphadenopathy. After admission to the trial appropriate surgical therapy was undertaken. The patients were then given either phenoxymethylpenicillin 250 mg four times daily, cephradine 500 mg twice daily or amoxycillin 250 mg three times daily, all for 5 days. The patients were assessed after 2 days and 5 days. All the patients recovered with those taking cephradine showing the best recovery in the first two days of treatment.

• Authors: M W Fazakerley, P McGowan, P Hardy, M V Martin
• Journal: British dental journal (Br Dent J) Vol. 174 Issue 10 Pg. 359-63 (May 22 1993) ISSN: 0007-0610 [Print] England
• PMID: 8494665 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Amoxicillin
• Cephradine
• Penicillin V

Topics

• Actinomyces (drug effects)
• Adolescent
• Adult
• Aged
• Amoxicillin (therapeutic use)
• Bacteroides (drug effects)
• Cephradine (therapeutic use)
• Double-Blind Method
• Female
• Haemophilus influenzae (drug effects)
• Humans
• Male
• Microbial Sensitivity Tests
• Middle Aged
• Pain Measurement
• Penicillin V (therapeutic use)
• Periapical Abscess (drug therapy, microbiology)
• Streptococcus (drug effects)
• Veillonella (drug effects)