[Efficacy of intravenous milrinone in the treatment of acute congestive cardiac failure. Results of a French multicenter study].
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| Abstract |
The hemodynamic effects and safety of milrinone, a phosphodiesterase inhibitor, were studied in 57 patients in the acute phase of cardiac failure. The drug was given intravenously as an initial push dose of 50 micrograms/kg in 10 min followed by a 24 hour infusion at the dose of 0.5 micrograms/kg/min. Maximal response was obtained after 15 min and persisted throughout the infusion. Cardiac index rose by 40%, while pulmonary capillary pressure fell from 25 mmHg to 17 mmHg (-30%) by the fifth minute of treatment. Mean pulmonary artery pressure fell by 20% by the 15th minute. Systemic resistance decreased by 26% and pulmonary vascular resistance by 22%. All these variations were significant. Heart rate and systemic blood pressure remained stable. Study of three sub-groups: digoxin vs non-digoxin, sinus rhythm vs atrial fibrillation, and coronary patients vs non-coronary patients, revealed no significant difference. Safety of the drug was good, no extra-cardiac actions having required interruption of the infusion. Stoppage was made necessary by two instances of ventricular tachycardia. Improved hemodynamic effects and the good safety/acceptability of the drug indicate that milrinone is a treatment of choice in cardiac failure.
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| Authors | J L Dubois-Randé, C Guérot, F Jan, M Brochier, A Sacrez, A Vacheron, M Bory, H Lambert, J C Pony, Y Le Bloc'h |
| Journal | Annales de cardiologie et d'angeiologie (Ann Cardiol Angeiol (Paris)) Vol. 42 Issue 2 Pg. 105-14 (Feb 1993) ISSN: 0003-3928 [Print] France |
| Vernacular Title | Efficacité de la milrinone intraveineuse dans le traitement de l'insuffisance cardiaque congestive aiguë. Résultats d'une étude multicentrique française. |
| PMID | 8494318 (Publication Type: Clinical Trial, English Abstract, Journal Article, Multicenter Study) |
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