[Loco-regional intra-arterial chemotherapy combined with radiotherapy in cervical carcinoma].

Abstract

Fifteen patients with squamous cell carcinoma of the uterine cervix--7 in stage II, 6 in stage III and 2 in stage IV--were considered not to respond at the end of radiotherapy. Therefore, the whole patient population underwent bilateral intraarterial chemotherapy with Mitomycin-C (3 cycles, 3-4 weeks' intervals). Patients' responses were evaluated with clinical and CT examinations following irradiation and after completing chemotherapy. Pelvic irradiation was administered by external beams (6 Mv), for a 50-Gy dosage (200 cGy/day for 5 weeks); in 4 cases treatment was completed by means of brachytherapy (192 Ir), with 20-25 Gy dosage. Intraarterial infusion was carried out after positioning the catheters in both uterine arteries; in 5 cases, the internal iliac artery alone was cannulated. At the end of the combined treatment, 2 patients (13%) responded completely, 9 (60%) partially and 4 (27%) not at all. Mean survival was 24 months. No hematologic complication was so severe that treatment had to be discontinued. In 4 patients chemotherapy caused a partially ulcerated skin erythema in the buttocks, which was completely cured in all cases.

• Authors: M Trinci, N Raffetto, F Salvatori, C Trinci
• Journal: La Radiologia medica (Radiol Med) Vol. 85 Issue 3 Pg. 262-5 (Mar 1993) ISSN: 0033-8362 [Print] Italy
• Vernacular Title: La chemioterapia intra-arteriosa loco-regionale associata alla radioterapia nel cervicocarcinoma.
• PMID: 8493375 (Publication Type: English Abstract, Journal Article)

Chemical References

• Mitomycin

Topics

• Carcinoma, Squamous Cell (drug therapy, radiotherapy, therapy)
• Combined Modality Therapy
• Female
• Humans
• Infusions, Intra-Arterial
• Mitomycin (administration & dosage, therapeutic use)
• Uterine Cervical Neoplasms (drug therapy, radiotherapy, therapy)