Abstract |
Cystinuria is an autosomal recessive hereditary disorder associated with nephrolithiasis and its attendant complications. Traditional management aimed at increasing urinary cystine solubility using oral alkali, D-penicillamine, or mercaptopropionyglycine is often unsuccessful due to intolerable side effects. Two cystinuric patients intolerant of traditional therapy were treated with captopril for 1 year, resulting in a marked decline in urinary cystine excretion. Neither patient experienced recurrent nephrolithiasis or adverse drug effects. Captopril should be considered an alternative to traditional drug management of cystinuria.
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Authors | M A Perazella, G K Buller |
Journal | American journal of kidney diseases : the official journal of the National Kidney Foundation
(Am J Kidney Dis)
Vol. 21
Issue 5
Pg. 504-7
(May 1993)
ISSN: 0272-6386 [Print] United States |
PMID | 8488818
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Captopril
(therapeutic use)
- Cystinuria
(drug therapy)
- Humans
- Male
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