Effect of nifedipine on kidney and ureteral function after experimental acute unilateral ureteral obstruction.

Abstract

Nifedipine, a calcium channel blocker, was tested for its in vivo effect on the ureter and kidney during acute obstruction. There was no discernible effect on peristalsis but glomerular filtration rate was improved. Thus, nifedipine would not be expected to decrease renal colic from obstruction.

• Authors: G M Ghoniem, J P Dilworth, J A Roberts
• Journal: Urology (Urology) Vol. 41 Issue 5 Pg. 484-8 (May 1993) ISSN: 0090-4295 [Print] United States
• PMID: 8488620 (Publication Type: Journal Article)

Chemical References

• Nifedipine

Topics

• Animals
• Colic (drug therapy)
• Glomerular Filtration Rate (drug effects)
• Kidney (drug effects, physiopathology)
• Kidney Diseases (drug therapy)
• Male
• Muscle Contraction (drug effects)
• Muscle, Smooth (drug effects, physiopathology)
• Nifedipine (pharmacology)
• Papio
• Radioisotope Renography
• Renal Circulation (drug effects)
• Ureter (drug effects, physiopathology)
• Ureteral Obstruction (physiopathology)