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[Effects of NC-1100, a calcium channel blocker, on experimental cerebral ischemia/anoxia in rodents].

Abstract
The anti-ischemic and anoxic effects of NC-1100, a piperazine type calcium channel blocker, were investigated in various cerebral ischemia and anoxia models in mice, gerbils and guinea pigs. Minimal effective doses of NC-1100 were 8 mg/kg, i.p. and 30 mg/kg, p.o. for KCN-induced anoxia; 16 mg/kg, i.p. for decapitation-induced gasping; 30 mg/kg, i.p. for cerebral ischemia induced by occlusion of bilateral carotid arteries in gerbils; and 10 microM for the in vitro ischemic model in hippocampal slices. Moreover, NC-1100 attenuated the disturbance of cerebral energy metabolism induced by decapitation in mice. These results suggest that NC-1100 has a cerebral protective effect, and that attributable to its ability to improve the cerebral energy metabolism disturbance.
AuthorsT Matsumura, H Furuichi, J Izumi, Y Kamatsuka, M Takei, N Nakata, S Ito, H Suda, K Kizaki, T Kurimoto
JournalNihon yakurigaku zasshi. Folia pharmacologica Japonica (Nihon Yakurigaku Zasshi) Vol. 101 Issue 3 Pg. 177-86 (Mar 1993) ISSN: 0015-5691 [Print] Japan
PMID8486322 (Publication Type: Journal Article)
Chemical References
  • Calcium Channel Blockers
  • Piperazines
  • tamolarizine
Topics
  • Animals
  • Brain (metabolism)
  • Brain Ischemia (drug therapy)
  • Calcium Channel Blockers (administration & dosage, pharmacology, therapeutic use)
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Energy Metabolism (drug effects)
  • Gerbillinae
  • Guinea Pigs
  • Hypoxia (drug therapy)
  • Male
  • Mice
  • Piperazines (administration & dosage, pharmacology, therapeutic use)

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