Abstract |
The anti-ischemic and anoxic effects of NC-1100, a piperazine type calcium channel blocker, were investigated in various cerebral ischemia and anoxia models in mice, gerbils and guinea pigs. Minimal effective doses of NC-1100 were 8 mg/kg, i.p. and 30 mg/kg, p.o. for KCN-induced anoxia; 16 mg/kg, i.p. for decapitation-induced gasping; 30 mg/kg, i.p. for cerebral ischemia induced by occlusion of bilateral carotid arteries in gerbils; and 10 microM for the in vitro ischemic model in hippocampal slices. Moreover, NC-1100 attenuated the disturbance of cerebral energy metabolism induced by decapitation in mice. These results suggest that NC-1100 has a cerebral protective effect, and that attributable to its ability to improve the cerebral energy metabolism disturbance.
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Authors | T Matsumura, H Furuichi, J Izumi, Y Kamatsuka, M Takei, N Nakata, S Ito, H Suda, K Kizaki, T Kurimoto |
Journal | Nihon yakurigaku zasshi. Folia pharmacologica Japonica
(Nihon Yakurigaku Zasshi)
Vol. 101
Issue 3
Pg. 177-86
(Mar 1993)
ISSN: 0015-5691 [Print] Japan |
PMID | 8486322
(Publication Type: Journal Article)
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Chemical References |
- Calcium Channel Blockers
- Piperazines
- tamolarizine
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Topics |
- Animals
- Brain
(metabolism)
- Brain Ischemia
(drug therapy)
- Calcium Channel Blockers
(administration & dosage, pharmacology, therapeutic use)
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Energy Metabolism
(drug effects)
- Gerbillinae
- Guinea Pigs
- Hypoxia
(drug therapy)
- Male
- Mice
- Piperazines
(administration & dosage, pharmacology, therapeutic use)
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