[Metabolic regulation on retinoic acid and vitamin E function].

Abstract

1. Retinoic acid is an oxidative metabolite which is produced intracellularly and plays role in gene expression via nuclear retinoic acid receptor (RAR), a family of steroid receptor. Recently, clinical use of retinoic acid in acute pro-myelocytic leukemia (APL) was proposed to induce complete remission in the leukemic cells, which have the t(15:17) of chromosomal anomaly producing a different protein from the normal RAR. From this clinical view, the regulatory role of retinoic acid is becoming clear in the cells. 2. Vitamin E is an antioxidant in biological membranes to prevent from their oxidative chain reaction occurring near the location of vitamin E in the lipid layer of the membranes. Thus, the location of vitamin E, especially alpha-tocopherol differing from the other analogues, in the living body is important to assess its function. From the standpoint of view, absorption of vitamin E from the gut, its circulation in the blood, and transportation to tissues and cells will be discussed in this paper.

• Authors: M Mino
• Journal: Nihon rinsho. Japanese journal of clinical medicine (Nihon Rinsho) Vol. 51 Issue 4 Pg. 871-8 (Apr 1993) ISSN: 0047-1852 [Print] Japan
• PMID: 8483267 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Vitamin E
• Tretinoin

Topics

• Humans
• Tretinoin (metabolism)
• Vitamin E (metabolism, physiology)