Abstract |
Acute and chronic osteomyelitis can be difficult to treat by conventional means. Current methods of treatment involve the use of systemic antibiotics, the local implantation of non-degradable drug carriers, and surgical débridement. Each method has specific drawbacks. We report on the use of a new controlled release system utilizing gentamicin and bioerodible, biocompatible polymers ( polyanhydrides) designed for drug delivery applications for the treatment of clinical osteomyelitis. We compared this system's ability to reduce bacterial levels in infected bone with that of conventional non-degradable delivery systems based on polymethylmethacrylate ( PMMA) and gentamicin. Polyanhydride copolymers of bis-carboxyphenoxypropane and sebacic acid P loaded with gentamicin sulfate and PMMA/ gentamicin matrices were implanted in the long bones of Sprague-Dawley rats infected with a strain of Staphylococcus aureus. After 3 weeks of implantation, the polymeric delivery devices were removed and quantitative cultures were used to determine bacterial levels in bone. The polyanhydride/ gentamicin matrices demonstrated significant degradation over the 3 week implantation period. Levels of bacteria, measured in colony forming units, were significantly lower in bone implanted with the polyanhydride/ gentamicin release system than in long bones of control animals without an implant (p < 0.01), of animals with a polyanhydride polymer implant alone (p < 0.01), and of animals with a PMMA/ gentamicin implant (p = 0.03). Bioerodible polyanhydrides show promise as a new treatment modality for infections in bone.
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Authors | C T Laurencin, T Gerhart, P Witschger, R Satcher, A Domb, A E Rosenberg, P Hanff, L Edsberg, W Hayes, R Langer |
Journal | Journal of orthopaedic research : official publication of the Orthopaedic Research Society
(J Orthop Res)
Vol. 11
Issue 2
Pg. 256-62
(Mar 1993)
ISSN: 0736-0266 [Print] United States |
PMID | 8483038
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Biocompatible Materials
- Decanoic Acids
- Dicarboxylic Acids
- Gentamicins
- Hydroxybenzoates
- Polymethacrylic Acids
- polymethacrylic acid
- sebacic acid
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Topics |
- Animals
- Biocompatible Materials
- Colony Count, Microbial
- Decanoic Acids
(administration & dosage)
- Dicarboxylic Acids
- Disease Models, Animal
- Gentamicins
(administration & dosage)
- Hydroxybenzoates
(administration & dosage)
- Male
- Osteomyelitis
(drug therapy, microbiology)
- Polymethacrylic Acids
(administration & dosage)
- Rats
- Rats, Sprague-Dawley
- Staphylococcal Infections
(drug therapy, microbiology)
- Staphylococcus aureus
(growth & development)
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