Abstract |
Aromatase inhibitors are known to be effective in the treatment of advanced postmenopausal breast cancer. To assess the efficacy of the aromatase inhibitor 4-hydroxyandrostenedione (4-OHA) as first-line treatment in patients who were either resistant to or had relapsed after adjuvant therapy, 50 eligible patients received intramuscular 4-OHA either 250 mg or 500 mg fortnightly until disease progression or severe adverse events. Of the 43 patients evaluable for clinical response (UICC criteria), 15 (36%) showed objective response (CR+PR), 6 (14%) stable disease (SD). In relation to disease site, objective responses were obtained in 55% of cases with soft tissue metastases (16/29); in 33% with visceral metastases (8/24), and in 24% with bone involvement (5/21). In relation to previous adjuvant treatment, there were eight objective responses among the 17 patients treated with chemotherapy (47%), and seven objective responses among the 24 treated with tamoxifen (29%). The treatment was well tolerated. These results support the hypothesis that adjuvant therapy, whether hormonal or chemotherapy, may make patients less responsive to subsequent treatment.
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Authors | E Bajetta, N Zilembo, R Buzzoni, C Noberasco, L Celio, E Bichisao |
Journal | Cancer treatment reviews
(Cancer Treat Rev)
Vol. 19 Suppl B
Pg. 31-6
(Apr 1993)
ISSN: 0305-7372 [Print] Netherlands |
PMID | 8481932
(Publication Type: Journal Article)
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Chemical References |
- Aromatase Inhibitors
- Tamoxifen
- Androstenedione
- Doxorubicin
- Cyclophosphamide
- formestane
- Fluorouracil
- Methotrexate
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Topics |
- Aged
- Androstenedione
(adverse effects, analogs & derivatives, therapeutic use)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Aromatase Inhibitors
- Breast Neoplasms
(drug therapy)
- Chemotherapy, Adjuvant
- Cyclophosphamide
(administration & dosage)
- Doxorubicin
(administration & dosage)
- Female
- Fluorouracil
(administration & dosage)
- Humans
- Menopause
- Methotrexate
(administration & dosage)
- Middle Aged
- Remission Induction
- Tamoxifen
(therapeutic use)
- Treatment Outcome
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