5-N-acetylardeemin, a novel heterocyclic compound which reverses multiple drug resistance in tumor cells. II. Isolation and elucidation of the structure of 5-N-acetylardeemin and two congeners.

Abstract

A family of novel compounds has been detected and isolated following an assay for the attenuation of multiple drug resistance in tumor cells from the fermentation broth and mycelia of a strain of Aspergillus fischeri which we have designated var. brasiliensis. The structures of three components were determined employing 1-D and 2-D homonuclear and heteronuclear NMR spectroscopy and mass spectrometry. The structure of 5-N-acetylardeemin was confirmed by single crystal X-ray diffraction. These compounds are most closely structurally related to asperlicin E1).

• Authors: J E Hochlowski, M M Mullally, S G Spanton, D N Whittern, P Hill, J B McAlpine
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 46 Issue 3 Pg. 380-6 (Mar 1993) ISSN: 0021-8820 [Print] England
• PMID: 8478256 (Publication Type: Journal Article)

Chemical References

• Antibiotics, Antineoplastic
• Heterocyclic Compounds
• Pyrimidinones
• 5-N-acetylardeemin

Topics

• Antibiotics, Antineoplastic (chemistry, isolation & purification, pharmacology)
• Aspergillus (chemistry)
• Drug Resistance, Microbial
• Heterocyclic Compounds (chemistry, isolation & purification, pharmacology)
• Humans
• Magnetic Resonance Spectroscopy
• Pyrimidinones (chemistry, isolation & purification, pharmacology)
• Tumor Cells, Cultured (drug effects)