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Continuous caudal anesthesia for inguinal hernia repair in former preterm infants.

AbstractSTUDY OBJECTIVE:
To determine the feasibility of continuous caudal anesthesia with 2-chloroprocaine in conscious former preterm infants undergoing inguinal hernia repair.
DESIGN:
Prospective study.
SETTING:
University-affiliated children's hospital.
PATIENTS:
Ten former preterm infants, ASA physical status II and III, who were 35 to 49.5 weeks postconceptional age at the time of surgery.
INTERVENTIONS:
Caudal anesthesia was administered via an indwelling catheter using a loading dose of 1 ml/kg (30 mg/kg) of 3% 2-chloroprocaine, followed by incremental doses of 0.3 ml/kg (9 mg/kg) to achieve a level of T4 to T2. The block was maintained by a minimum infusion rate of 30 mg/kg/hr (1 ml/kg/hr) of the same local anesthetic solution.
MEASUREMENTS AND MAIN RESULTS:
The mean cumulative dose of 2-chloroprocaine was 2.8 +/- 1.0 ml/kg/hr (84 +/- 30 mg/kg/hr) infused over a mean duration of 95 +/- 35 minutes. Serum cholinesterase concentration and plasma 2-chloroprocaine concentration were measured in five infants.
CONCLUSIONS:
Three percent 2-chloroprocaine can be used effectively for continuous caudal anesthesia in conscious, former preterm infants for inguinal hernia and penoscrotal surgical procedures lasting 85 to 170 minutes.
AuthorsK Henderson, N F Sethna, C B Berde
JournalJournal of clinical anesthesia (J Clin Anesth) 1993 Mar-Apr Vol. 5 Issue 2 Pg. 129-33 ISSN: 0952-8180 [Print] United States
PMID8476619 (Publication Type: Journal Article)
Chemical References
  • Anesthetics, Local
  • Procaine
  • chloroprocaine
  • Cholinesterases
Topics
  • Anesthesia, Caudal
  • Anesthetics, Local (administration & dosage, blood, pharmacology)
  • Blood Pressure (drug effects)
  • Cholinesterases (blood)
  • Gestational Age
  • Heart Rate (drug effects)
  • Hernia, Inguinal (surgery)
  • Humans
  • Infant
  • Infant, Newborn
  • Infant, Premature
  • Procaine (administration & dosage, analogs & derivatives, blood, pharmacology)
  • Prospective Studies

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