This study was performed to assess the
analgesic effect and the onset of action of
meclofenamic acid compared with naproxene in patients affected by acute lumbar-sciatic
pain. Thirty patients of both sexes were randomly allocated to 2 groups of 15 patients each; the first group was treated with
meclofenamic acid (200 mg b.i.d.) and the second with naproxene (500 mg b.i.d.). Both drugs were administered as
suppositories for a week. The intensity of
pain, both at rest and after movement, was assessed by means of analogic scales at basal time and 15, 30, 60, 180, 360 minutes, 4 and 8 days after the first administration. Both types of
pain were significantly decreased with respect to basal values in
meclofenamic acid group (P < 0.01), 60 minutes after onset of treatment, while in the naproxene group the effect was later. Moreover the
analgesic effect was significantly greater in the
meclofenamic acid group with respect to the naproxene group, after 15 minutes for
pain at rest (P < 0.05) and after 30 minutes for
pain after movement (P < 0.02). Similarly, after 4 and 8 days, both types of
pain improved to a larger extent in the
meclofenamic acid group with respect to the naproxene group (P < 0.05 after four days and P < 0.01 after eight days). This study has shown that
meclofenamic acid has greater efficacy and faster
analgesic effect than naproxene.
Meclofenamic acid has proved to be a
drug of choice in the treatment of slight to moderate musculo-skeletal
pain syndromes.