Abstract |
To evaluate the efficacy and safety of splenectomy in patients with human immunodeficiency virus (HIV)-related thrombocytopenia, 30 HIV-infected patients with thrombocytopenia (platelet count < 50 x 10(9)/l) who underwent splenectomy were followed prospectively for a mean period of 42 months. There were no perioperative deaths and morbidity was minimal. Twenty-one patients had a persistent complete response, six had a partial response and were asymptomatic after splenectomy, and only three showed no response. Three patients developed acquired immune deficiency syndrome during follow-up, an incidence that was no different from that expected. Splenectomy is a safe and effective treatment in HIV-infected patients with severe symptomatic thrombocytopenic purpura resistant to medical therapy.
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Authors | M Alonso, D Gossot, E Bourstyn, M J Galera, E Oksenhendler, M Celerier, P Clot |
Journal | The British journal of surgery
(Br J Surg)
Vol. 80
Issue 3
Pg. 330-3
(Mar 1993)
ISSN: 0007-1323 [Print] England |
PMID | 8472143
(Publication Type: Journal Article, Review)
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Topics |
- Adolescent
- Adult
- Female
- Follow-Up Studies
- HIV Infections
(complications)
- Humans
- Male
- Platelet Count
- Prospective Studies
- Splenectomy
- Thrombocytopenia
(complications, surgery)
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