HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Anti-interleukin-2 receptor monoclonal antibody therapy supports a role for Th1-like cells in HgCl2-induced autoimmunity in rats.

Abstract
Brown-Norway (BN) rats injected with HgCl2 develop an autoimmune disease characterized by a T-dependent polyclonal B-cell activation. Increase in major histocompatibility complex class II molecule expression on B cells concomitant with enhancement of serum IgE concentration supports the involvement of the T helper 2 (Th2)-like subset in the induction of the disease. The mercury disease is autoregulated and does not develop in Lewis (LEW) rats. Considering the reciprocal regulation, well defined in mice, between the Th1 and Th2 subsets, we addressed the role of the Th1-like subset in this disease. Brown-Norway and LEW rats injected with HgCl2 were treated with NDS61, a mouse anti-rat-IL-2R MoAb that blocks mainly Th1 cells. Data reported herein show that: (1) HgCl2 treatment does not modify either the percentage of IL-2R+ cells or IL-2R expression in both BN and LEW rats; (2) treatment of BN rats with NDS61 MoAb does not modify the induction phase of the mercury disease but delays in part the regulation phase; (3) such a treatment leads to some immune abnormalities in LEW rats; (4) HgCl2 markedly potentiates the anti-mouse Ig antibody response in BN rats which probably limits the effect of this treatment. This study supports a role for the Th1-like subset in HgCl2-induced autoimmunity in the rat.
AuthorsD Dubey, J Kuhn, M C Vial, P Druet, B Bellon
JournalScandinavian journal of immunology (Scand J Immunol) Vol. 37 Issue 4 Pg. 406-12 (Apr 1993) ISSN: 0300-9475 [Print] England
PMID8469923 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Monoclonal
  • Receptors, Interleukin-2
  • Immunoglobulin E
  • Mercuric Chloride
Topics
  • Animals
  • Antibodies, Monoclonal (therapeutic use)
  • Autoimmune Diseases (immunology)
  • Autoimmunity (immunology)
  • Disease Models, Animal
  • Female
  • Immunoglobulin E (analysis)
  • Mercuric Chloride
  • Rats
  • Rats, Inbred BN
  • Rats, Inbred Lew
  • Receptors, Interleukin-2 (immunology)
  • T-Lymphocyte Subsets (drug effects, immunology)
  • T-Lymphocytes, Helper-Inducer (drug effects, immunology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: