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Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial. UBC MS/MRI Study Group and the IFNB Multiple Sclerosis Study Group.

Abstract
We performed yearly MRI analyses on 327 of the total 372 patients in a multicenter, randomized, double-blind, placebo-controlled trial of interferon beta-1b (IFNB). Clinical results are presented in the preceding companion paper. Baseline MRI characteristics were the same in all treatment groups. Fifty-two patients at one center formed a cohort for frequent MRIs (one every 6 weeks) for analysis of disease activity. The MRI results support the clinical results in showing a significant reduction in disease activity as measured by numbers of active scans (median 80% reduction, p = 0.0082) and appearance of new lesions. In addition, there was an equally significant reduction in MRI-detected burden of disease in the treatment as compared with placebo groups (mean group difference of 23%, p = 0.001). These results demonstrate that IFNB has made a significant impact on the natural history of MS in these patients.
AuthorsD W Paty, D K Li
JournalNeurology (Neurology) Vol. 43 Issue 4 Pg. 662-7 (Apr 1993) ISSN: 0028-3878 [Print] UNITED STATES
PMID8469319 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Interferon-beta
Topics
  • Adult
  • Double-Blind Method
  • Female
  • Follow-Up Studies
  • Humans
  • Interferon-beta (therapeutic use)
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Multiple Sclerosis (diagnosis, therapy)
  • Recurrence
  • Treatment Outcome

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