Interleukin-1 alpha and tumour necrosis factor inhibit rat gastric fundus motility in vitro.

Abstract

In this study, the effects of tumour necrosis factor (TNF) and interleukins 1 alpha and 6 (IL-1 alpha and IL-6) on rat gastric fundus motility were investigated in vitro. IL-1 alpha and TNF induced rapid dose-dependent inhibition of stomach motility, with maximal relaxation equal to that induced by 100 microM papaverin, and respective EC50s of 20 and 450 pg/ml. IL-6 had no effect on gastric motility up to a 3 ng/ml concentration.

• Authors: P Montuschi, P Preziosi, P Navarra
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 233 Issue 2-3 Pg. 303-4 (Mar 23 1993) ISSN: 0014-2999 [Print] Netherlands
• PMID: 8467878 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Interleukin-1
• Interleukin-6
• Tumor Necrosis Factor-alpha
• Papaverine

Topics

• Animals
• Dose-Response Relationship, Drug
• Female
• Gastric Fundus (drug effects)
• Gastrointestinal Motility (drug effects)
• Interleukin-1 (pharmacology)
• Interleukin-6 (pharmacology)
• Male
• Muscle Relaxation (drug effects)
• Papaverine (pharmacology)
• Rats
• Rats, Wistar
• Tumor Necrosis Factor-alpha (pharmacology)