| Abstract | In this study, the effects of tumour necrosis factor (TNF) and interleukins 1 alpha and 6 (IL-1 alpha and IL-6) on rat gastric fundus motility were investigated in vitro. IL-1 alpha and TNF induced rapid dose-dependent inhibition of stomach motility, with maximal relaxation equal to that induced by 100 microM papaverin, and respective EC50s of 20 and 450 pg/ml. IL-6 had no effect on gastric motility up to a 3 ng/ml concentration. |
| Authors | P Montuschi, P Preziosi, P Navarra
(Affiliation: Department of Pharmacology, Catholic University Medical School, Rome, Italy.)
|
| Journal | European journal of pharmacology
(Eur J Pharmacol)
Vol. 233
Issue 2-3
Pg. 303-4
(Mar 23 1993)
ISSN: 0014-2999 NETHERLANDS |
| PMID | 8467878
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Interleukin-1
- Interleukin-6
- Tumor Necrosis Factor-alpha
- Papaverine
|
| Topics |
- Animals
- Dose-Response Relationship, Drug
- Female
- Gastric Fundus
(drug effects)
- Gastrointestinal Motility
(drug effects)
- Interleukin-1
(pharmacology)
- Interleukin-6
(pharmacology)
- Male
- Muscle Relaxation
(drug effects)
- Papaverine
(pharmacology)
- Rats
- Rats, Wistar
- Tumor Necrosis Factor-alpha
(pharmacology)
|
