The novel 5-HT4 receptor antagonist DAU 6285 antagonizes 5-hydroxytryptamine-induced tachycardia in pigs.

Abstract

The 5-HT4 receptor antagonist action of DAU 6285 was investigated in vivo in anesthetized pigs. DAU 6285 (0.3-3 mg/kg i.v.) dose dependently antagonized 5-hydroxytryptamine (5-HT)-induced tachycardiac responses. In contrast, the 5-HT3 receptor antagonist, ondansetron (0.3-3 mg/kg i.v.) did not influence the tachycardia induced by 5-HT. These results indicate that DAU 6285 is a potent antagonist of 5-HT4 receptor-mediated responses in vivo.

• Authors: J C Van Meel, W Diederen, R Haigh, W Wienen, M Pairet, M Turconi, H N Doods
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 233 Issue 2-3 Pg. 295-7 (Mar 23 1993) ISSN: 0014-2999 [Print] Netherlands
• PMID: 8467876 (Publication Type: Journal Article)

Chemical References

• Benzimidazoles
• Bridged Bicyclo Compounds
• Bridged Bicyclo Compounds, Heterocyclic
• Serotonin Antagonists
• DAU 6285
• Serotonin

Topics

• Animals
• Benzimidazoles (pharmacology)
• Bridged Bicyclo Compounds (pharmacology)
• Bridged Bicyclo Compounds, Heterocyclic
• Dose-Response Relationship, Drug
• Male
• Serotonin (toxicity)
• Serotonin Antagonists (pharmacology)
• Swine
• Tachycardia (chemically induced, prevention & control)