Abstract | BACKGROUND:
Dyslipidemia constitutes a serious health problem that should be diagnosed and treated by the family physician. Little is known about the efficacy of typical dietary therapy for patients with abnormal cholesterol levels. This study was the first large prospective family practice evaluation of the effectiveness of diet-and- exercise therapy followed by a pharmacologic intervention for those patients who remained dyslipidemic. METHODS: Patients who met standard criteria for cardiovascular disease risk based on lipid analysis were enrolled in a typical 6-week physician-directed diet-and-exercise program. Those patients who were still dyslipidemic after that period were started on 12 weeks of pharmacologic treatment with gemfibrozil. RESULTS: CONCLUSIONS: These findings suggest that in a typical clinical setting, a nonpharmacologic intervention of diet and exercise may not produce the desired overall lipid changes in the majority of dyslipidemic patients.
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Authors | W J Stelmach, D R Rush, P C Brucker, E J Schaefer, H E Holverson, W J Kane, B L Huffman Jr |
Journal | The Journal of family practice
(J Fam Pract)
Vol. 36
Issue 4
Pg. 401-8
(Apr 1993)
ISSN: 0094-3509 [Print] United States |
PMID | 8463782
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dietary Fats
- Triglycerides
- Cholesterol
- Gemfibrozil
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Topics |
- Cholesterol
(blood)
- Combined Modality Therapy
- Dietary Fats
(administration & dosage)
- Exercise
- Family Practice
- Female
- Gemfibrozil
(adverse effects, therapeutic use)
- Humans
- Hyperlipidemias
(blood, therapy)
- Male
- Middle Aged
- Patient Compliance
- Prospective Studies
- Time Factors
- Triglycerides
(blood)
- United States
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