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Molecular basis of rifampin resistance in Mycobacterium leprae.

Abstract
Rifampin is currently the most potent drug used in leprosy control programs. We show that the rifampin resistance which emerged in nine patients with lepromatous leprosy, who had received rifampin monotherapy, stemmed from mutations in the rpoB gene, which encodes the beta subunit of RNA polymerase of Mycobacterium leprae. In eight cases missense mutations were found to affect a serine residue, Ser-425, while in the remaining mutant a small insertion was found close to this site. These findings will be of use for the development of a rapid screening procedure, involving the polymerase chain reaction, for monitoring the emergence of rifampin-resistant M. leprae strains.
AuthorsN Honore, S T Cole
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 37 Issue 3 Pg. 414-8 (Mar 1993) ISSN: 0066-4804 [Print] United States
PMID8460911 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Rifampin
Topics
  • Amino Acid Sequence (drug effects)
  • Animals
  • Base Sequence (drug effects)
  • Conserved Sequence (drug effects)
  • Drug Resistance, Microbial
  • Genes, Bacterial (drug effects)
  • Humans
  • Leprosy (diagnosis, genetics, microbiology)
  • Mice
  • Molecular Sequence Data
  • Mutation (drug effects)
  • Mycobacterium leprae (drug effects, genetics)
  • Rifampin (pharmacology)

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