Cocarcinogenic effects of n-alkanes and ultraviolet light on mice.

Abstract

A comparison was made of the effects of repeated topical applications to mice of three n-paraffins (n-decane), n-dodecane, and n-tetradecane) on the carcinogenic potential of UV light at three wavelength regions: 254 nm, 290-320 nm, and greater than 350 nm. All three n-alkanes had a cocarcinogenic effect at 254 nm, whereas only n-dodecane was effective from 290 to 320 nm. Radiation at wavelengths longer than 350 nm, generally considered noncarcinogenic, produced tumors on the backs of mice treated with n-decane or n-tetradecane.

• Authors: E Bingham, P J Nord
• Journal: Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 58 Issue 4 Pg. 1099-101 (Apr 1977) ISSN: 0027-8874 [Print] United States
• PMID: 845980 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Alkanes

Topics

• Alkanes (toxicity)
• Animals
• Cocarcinogenesis
• Male
• Mice
• Mice, Inbred C3H
• Neoplasms, Experimental (etiology)
• Neoplasms, Radiation-Induced (etiology)
• Skin Neoplasms (etiology)
• Ultraviolet Rays (adverse effects)