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Piperacillin monotherapy compared with metronidazole and gentamicin combination in penetrating abdominal trauma.

Abstract
The therapeutic efficacy and safety of piperacillin (4.5 g, every 6 hours) were compared with combined gentamicin (80 mg, every 8 hours) and metronidazole (500 mg every 6 hours) therapy in 246 patients hospitalized for penetrating abdominal injuries. Sixty-five patients had penetrating injury of the colon, rectum, or terminal ileum. The overall clinical cure rate was about 94% in both treatment groups. Adverse clinical experiences or biochemical abnormalities required discontinuation of therapy in three patients on gentamicin/metronidazole and in no patients on piperacillin.
AuthorsE H Sims, M A Lou, S W Williams, N Ganesan, H Thadepalli
JournalThe Journal of trauma (J Trauma) Vol. 34 Issue 2 Pg. 205-10 (Feb 1993) ISSN: 0022-5282 [Print] United States
PMID8459456 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Gentamicins
  • Metronidazole
  • Piperacillin
Topics
  • Abdominal Injuries (surgery)
  • Adolescent
  • Adult
  • Aged
  • Drug Administration Schedule
  • Drug Therapy, Combination (therapeutic use)
  • Female
  • Gentamicins (administration & dosage)
  • Humans
  • Male
  • Metronidazole (administration & dosage)
  • Middle Aged
  • Piperacillin (administration & dosage, therapeutic use)
  • Surgical Wound Infection (prevention & control)
  • Wounds, Penetrating (surgery)

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