Abstract |
The therapeutic efficacy and safety of piperacillin (4.5 g, every 6 hours) were compared with combined gentamicin (80 mg, every 8 hours) and metronidazole (500 mg every 6 hours) therapy in 246 patients hospitalized for penetrating abdominal injuries. Sixty-five patients had penetrating injury of the colon, rectum, or terminal ileum. The overall clinical cure rate was about 94% in both treatment groups. Adverse clinical experiences or biochemical abnormalities required discontinuation of therapy in three patients on gentamicin/ metronidazole and in no patients on piperacillin.
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Authors | E H Sims, M A Lou, S W Williams, N Ganesan, H Thadepalli |
Journal | The Journal of trauma
(J Trauma)
Vol. 34
Issue 2
Pg. 205-10
(Feb 1993)
ISSN: 0022-5282 [Print] United States |
PMID | 8459456
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Gentamicins
- Metronidazole
- Piperacillin
|
Topics |
- Abdominal Injuries
(surgery)
- Adolescent
- Adult
- Aged
- Drug Administration Schedule
- Drug Therapy, Combination
(therapeutic use)
- Female
- Gentamicins
(administration & dosage)
- Humans
- Male
- Metronidazole
(administration & dosage)
- Middle Aged
- Piperacillin
(administration & dosage, therapeutic use)
- Surgical Wound Infection
(prevention & control)
- Wounds, Penetrating
(surgery)
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