Presence of N-methyldopamine in parkinsonian and normal human brains.

Abstract

N-Methyldopamine (epinine) has been identified for the first time in parkinsonian and normal human brains by gas chromatography-mass spectrometry. N-Methylsalsolinol and N-methylnorsalsolinol, which are analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, which produces parkinsonism in humans, may be synthesized from N-methyldopamine by the Pictet-Spengler condensation reaction as an alternative metabolic pathway.

• Authors: M Kajita, T Niwa, N Takeda, H Yoshizumi, A Tatematsu, K Watanabe, T Nagatsu
• Journal: Journal of chromatography (J Chromatogr) Vol. 613 Issue 1 Pg. 1-8 (Mar 05 1993) Netherlands
• PMID: 8458887 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Isoquinolines
• Salsoline Alkaloids
• Tetrahydroisoquinolines
• 2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline
• salsoline
• Deoxyepinephrine

Topics

• Brain (metabolism)
• Deoxyepinephrine (metabolism)
• Gas Chromatography-Mass Spectrometry
• Humans
• Isoquinolines (metabolism)
• Parkinson Disease (metabolism)
• Salsoline Alkaloids (metabolism)
• Tetrahydroisoquinolines