Abstract |
Chemically synthesized (+)- goniopypyrone was found to suppress the growth of cultured Ehrlich ascites tumor cells as well as PU5-1.8 cells. The ED50 values were found to be 35 and 30 micrograms/ml for the two cell lines used. An LD50 of 193 micrograms/ml was observed in the brine shrimp bioassay.
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Authors | T K Shing, M Look, Y M Choy |
Journal | Chemotherapy
(Chemotherapy)
1993 Mar-Apr
Vol. 39
Issue 2
Pg. 132-4
ISSN: 0009-3157 [Print] Switzerland |
PMID | 8458246
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Lactones
- Styrenes
- goniopypyrone
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Topics |
- Animals
- Antineoplastic Agents, Phytogenic
(pharmacology)
- Carcinoma, Ehrlich Tumor
(drug therapy)
- Cell Line
- Humans
- Lactones
(chemical synthesis, pharmacology)
- Styrenes
(chemical synthesis, pharmacology)
- Tumor Cells, Cultured
(drug effects)
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