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Antitumor effect of chemically synthesized (+)-goniopypyrone.

Abstract
Chemically synthesized (+)-goniopypyrone was found to suppress the growth of cultured Ehrlich ascites tumor cells as well as PU5-1.8 cells. The ED50 values were found to be 35 and 30 micrograms/ml for the two cell lines used. An LD50 of 193 micrograms/ml was observed in the brine shrimp bioassay.
AuthorsT K Shing, M Look, Y M Choy
JournalChemotherapy (Chemotherapy) 1993 Mar-Apr Vol. 39 Issue 2 Pg. 132-4 ISSN: 0009-3157 [Print] Switzerland
PMID8458246 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Antineoplastic Agents, Phytogenic
  • Lactones
  • Styrenes
  • goniopypyrone
Topics
  • Animals
  • Antineoplastic Agents, Phytogenic (pharmacology)
  • Carcinoma, Ehrlich Tumor (drug therapy)
  • Cell Line
  • Humans
  • Lactones (chemical synthesis, pharmacology)
  • Styrenes (chemical synthesis, pharmacology)
  • Tumor Cells, Cultured (drug effects)

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