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In vitro activity of a new antibacterial drug, trospectomycin sulphate (U-63,366F), against Bacteroides strains isolated from the vagina.

Abstract
The antibacterial activity of trospectomycin, clindamycin, metronidazole, imipenem, cefoxitin, and piperacillin was tested against 72 Bacteroides spp. strains isolated from the vagina of women with vaginitis by determining the minimal inhibitory concentration using the agar dilution method. Trospectomycin shows a good activity which is comparable to that of imipenem and metronidazole. Its expanded spectrum of activity makes trospectomycin suitable for the use in single-drug therapy of pelvic infections in women.
AuthorsG P Testore, L Terranova, A Salanitro, P Sordillo, A Foli, F Giacomello, M Andreoni
JournalChemotherapy (Chemotherapy) 1993 Mar-Apr Vol. 39 Issue 2 Pg. 124-7 ISSN: 0009-3157 [Print] Switzerland
PMID8458245 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • trospectomycin
  • Spectinomycin
Topics
  • Bacteroides (drug effects, isolation & purification)
  • Female
  • Humans
  • Microbial Sensitivity Tests
  • Species Specificity
  • Spectinomycin (analogs & derivatives, pharmacology)
  • Vagina (microbiology)

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