HLA class II alleles and heterogeneity of juvenile rheumatoid arthritis. DRB1*0101 may define a novel subset of the disease.

Abstract

OBJECTIVE:

To examine the distribution of HLA class II alleles in clinically distinct juvenile rheumatoid arthritis (JRA) subsets.

METHODS:

We typed 298 patients and 181 controls for HLA-DRB1, DQA1, DQB1, and DPB1 alleles using polymerase chain reaction and oligonucleotide probe techniques.

RESULTS:

Each JRA subset was characterized by a distinct distribution of HLA class II alleles. For the persistently pauciarticular and rheumatoid factor-negative polyarticular JRA subsets, certain combinations of DRB1 and DPB1 alleles were characteristic. In patients without antinuclear antibodies and chronic iridocyclitis, there was an increase of DRB1*0101/02 and DQA1*0101.

CONCLUSION:

Findings of HLA typing support clinical subdivisions of the disease and suggest the existence of a novel DRB1*0101/02 and DQA1*0101 associated disease subset.

• Authors: R Ploski, O Vinje, K S Rønningen, A Spurkland, D Sørskaar, F Vartdal, O Førre
• Journal: Arthritis and rheumatism (Arthritis Rheum) Vol. 36 Issue 4 Pg. 465-72 (Apr 1993) ISSN: 0004-3591 [Print] United States
• PMID: 8457222 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Antinuclear
• HLA-DP Antigens
• HLA-DQ Antigens
• HLA-DQ alpha-Chains
• HLA-DQA1 antigen
• HLA-DR Antigens
• HLA-DRB1 Chains
• Histocompatibility Antigens Class II

Topics

• Aging (genetics)
• Alleles
• Antibodies, Antinuclear (blood)
• Arthritis, Juvenile (epidemiology, genetics, immunology)
• Child
• Child, Preschool
• Female
• HLA-DP Antigens
• HLA-DQ Antigens (genetics)
• HLA-DQ alpha-Chains
• HLA-DR Antigens (genetics)
• HLA-DRB1 Chains
• Histocompatibility Antigens Class II (genetics)
• Histocompatibility Testing
• Humans
• Infant
• Iridocyclitis (blood, immunology)
• Male
• Risk Factors