Abstract | OBJECTIVE: METHODS: We typed 298 patients and 181 controls for HLA-DRB1, DQA1, DQB1, and DPB1 alleles using polymerase chain reaction and oligonucleotide probe techniques. RESULTS: Each JRA subset was characterized by a distinct distribution of HLA class II alleles. For the persistently pauciarticular and rheumatoid factor-negative polyarticular JRA subsets, certain combinations of DRB1 and DPB1 alleles were characteristic. In patients without antinuclear antibodies and chronic iridocyclitis, there was an increase of DRB1*0101/02 and DQA1*0101. CONCLUSION: Findings of HLA typing support clinical subdivisions of the disease and suggest the existence of a novel DRB1*0101/02 and DQA1*0101 associated disease subset.
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Authors | R Ploski, O Vinje, K S Rønningen, A Spurkland, D Sørskaar, F Vartdal, O Førre |
Journal | Arthritis and rheumatism
(Arthritis Rheum)
Vol. 36
Issue 4
Pg. 465-72
(Apr 1993)
ISSN: 0004-3591 [Print] United States |
PMID | 8457222
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Antinuclear
- HLA-DP Antigens
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- HLA-DQA1 antigen
- HLA-DR Antigens
- HLA-DRB1 Chains
- Histocompatibility Antigens Class II
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Topics |
- Aging
(genetics)
- Alleles
- Antibodies, Antinuclear
(blood)
- Arthritis, Juvenile
(epidemiology, genetics, immunology)
- Child
- Child, Preschool
- Female
- HLA-DP Antigens
- HLA-DQ Antigens
(genetics)
- HLA-DQ alpha-Chains
- HLA-DR Antigens
(genetics)
- HLA-DRB1 Chains
- Histocompatibility Antigens Class II
(genetics)
- Histocompatibility Testing
- Humans
- Infant
- Iridocyclitis
(blood, immunology)
- Male
- Risk Factors
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