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6-Dimethylamino-9-(beta-D-arabinofuranosyl)-9H-purine: pharmacokinetics and antiviral activity in simian varicella virus-infected monkeys.

Abstract
6-Dimethylamino-9-(beta-D-arabinofuranosyl)-9H-purine (ara-DMAP) effectively prevented the development of rash and appreciably reduced viremia in simian varicella virus-infected monkeys. Doses of 100 and 50 mg/kg/day, administered orally, were highly effective. The lowest dose of 20 mg/kg/day was much less effective in preventing moderate viremia. However, the 20 mg/kg/day did prevent the development of rash in two of three monkeys. All three doses of ara-DMAP reduced liver infection as reflected by lower aspartate aminotransferase values in the sera of the African green monkeys. Orally administered ara-DMAP was rapidly absorbed. However, significant variation among individual monkeys in the AUC values, peak plasma levels, and plasma half-lives were observed.
AuthorsK F Soike, J L Huang, C U Lambe, D J Nelson, M N Ellis, T A Krenitsky, G W Koszalka
JournalAntiviral research (Antiviral Res) Vol. 20 Issue 1 Pg. 13-20 (Jan 1993) ISSN: 0166-3542 [Print] Netherlands
PMID8457145 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • 6-dimethylaminopurine arabinoside
  • Antiviral Agents
  • Aspartate Aminotransferases
  • Vidarabine
Topics
  • Administration, Oral
  • Animals
  • Animals, Wild
  • Antiviral Agents (blood, pharmacokinetics, therapeutic use)
  • Aspartate Aminotransferases (blood)
  • Chickenpox (drug therapy)
  • Chlorocebus aethiops
  • Drug Evaluation
  • Half-Life
  • Relative Biological Effectiveness
  • Skin (pathology)
  • Treatment Outcome
  • Vidarabine (administration & dosage, analogs & derivatives, pharmacokinetics, therapeutic use)
  • Viremia (drug therapy)

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