Tryptase in nasal fluid is a useful marker of allergic rhinitis.

Abstract

Tryptase is a mast cell-specific marker of degranulation. To investigate the possible diagnostic value of tryptase in allergic rhinitis, we measured the levels in both serum and native nasal fluid with a sandwich RIA-assay (Pharmacia). Twenty-three allergic patients and five patients with chronic ethmoidal sinusitis were included. Eighteen of the 23 allergic patients were tested within the pollen season or had perennial rhinitis; the remainder were tested at least 1 month out of the pollen season. None of the patients had detectable serum tryptase (> 0.1 ng/ml). Also patients with chronic ethmoidal sinusitis showed no tryptase in nasal fluid. One of seven allergic patients tested out of season had slightly increased nasal tryptase of 1.8 ng/ml. In patients with active nasal allergy, the tryptase in nasal fluid ranged from 6.4 ng/ml to 640 ng/ml with a mean of 101 ng/ml and SD 173. These results show a clear distinction between active and non-active nasal allergy and other non-mast-cell-related nasal disease. Further, nasal tryptase release by natural allergen exposure is even higher than that observed in allergen challenge tests.

• Authors: G Rasp, K Hochstrasser
• Journal: Allergy (Allergy) Vol. 48 Issue 2 Pg. 72-4 (Feb 1993) ISSN: 0105-4538 [Print] Denmark
• PMID: 8457035 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Serine Endopeptidases
• chymase 2
• Chymases
• Tryptases

Topics

• Biomarkers
• Chymases
• Humans
• Nasal Mucosa (enzymology)
• Rhinitis, Allergic, Perennial (enzymology)
• Rhinitis, Allergic, Seasonal (enzymology)
• Serine Endopeptidases (analysis)
• Tryptases