Lazaroid antioxidant reduces incidence of diabetes and insulitis in nonobese diabetic mice.

Abstract

Oxygen free radicals have been implicated as mediators of pancreatic islet beta cell damage in autoimmune, insulin-dependent diabetes mellitus (IDDM). We examined the effects of a potent antioxidant compound, U78518F, on the incidence of diabetes and pancreatic islet infiltration with lymphocytes and monocytes (insulitis) in the non-obese diabetic (NOD) mouse, an animal model for human IDDM. U78518F, administered to NOD mice from age 8 to 30 weeks, produced a dose-dependent decrease in diabetes incidence, from 89% (16/18 control NOD mice) to 61% (11/18 NOD mice treated with 2 mg/kg/day U78518F, p < 0.05) and 44% (8/18 NOD mice treated with 16 mg/kg/day U78518F, p < 0.005). Protection against diabetes was associated with significant decreases in pancreatic insulitis and prevention of beta cell loss in the U78518F-treated NOD mice. These results suggest that antioxidants may have therapeutic application in attempts to prevent immune-mediated islet beta cell damage and IDDM.

• Authors: A Rabinovitch, W L Suarez, R F Power
• Journal: The Journal of laboratory and clinical medicine (J Lab Clin Med) Vol. 121 Issue 4 Pg. 603-7 (Apr 1993) ISSN: 0022-2143 [Print] United States
• PMID: 8454942 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antioxidants
• Ethylamines
• Insulin
• Piperazines
• Pyridines
• U 78518F

Topics

• Animals
• Antioxidants (pharmacology)
• Autoimmune Diseases (prevention & control)
• Cell Death (drug effects)
• Diabetes Mellitus, Type 1 (immunology, metabolism, prevention & control)
• Dose-Response Relationship, Drug
• Ethylamines (pharmacology)
• Female
• Incidence
• Insulin (metabolism)
• Islets of Langerhans (drug effects, immunology, metabolism, pathology)
• Mice
• Mice, Inbred BALB C
• Mice, Inbred NOD
• Piperazines (pharmacology)
• Pyridines (pharmacology)