The use of gemfibrozil in a patient with chronic myelogenous leukemia to successfully manage retinoid-induced hypertriglyceridemia.

Systemic retinoids are used in the management of chronic cutaneous conditions and life-threatening dermatoses. Unfortunately, drug-induced hypertriglyceridemia may necessitate either dose reduction or discontinuation of therapy. The purpose of this article is to describe the successful management of isotretinoin-induced hypertriglyceridemia with gemfibrozil in a leukemia patient. Sequential serum chemistries were performed prior to, during, and following treatment with a systemic retinoid and a lipid-regulating agent. A prompt and sustained normalization of fasting triglycerides occurred following the initiation of gemfibrozil in a patient with isotretinoin-induced hypertriglyceridemia. When retinoids are being used in the management of serious conditions, the initiation of therapy with gemfibrozil to reduce the elevated triglycerides may be appropriate in those patients with retinoid-induced hypertriglyceridemia.
AuthorsP R Cohen
JournalThe Clinical investigator (Clin Investig) Vol. 71 Issue 1 Pg. 74-7 (Jan 1993) ISSN: 0941-0198 [Print] GERMANY
PMID8453265 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Immunologic Factors
  • Cytarabine
  • Isotretinoin
  • Gemfibrozil
  • Hydroxyurea
  • Acne Vulgaris (complications, drug therapy)
  • Adult
  • Combined Modality Therapy
  • Cytarabine (therapeutic use)
  • Gemfibrozil (therapeutic use)
  • Humans
  • Hydroxyurea (therapeutic use)
  • Hypertriglyceridemia (chemically induced, drug therapy, epidemiology)
  • Immunologic Factors (therapeutic use)
  • Incidence
  • Isotretinoin (adverse effects)
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive (complications, drug therapy, therapy)
  • Male

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