Antitumor-promoting activity of scopadulcic acid B, isolated from the medicinal plant Scoparia dulcis L.

Abstract

Scopadulcic acid B (SDB), a tetracyclic diterpenoid isolated from a medicinal plant, Scoparia dulcis L., inhibited the effects of tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in vitro and in vivo; SDB inhibited TPA-enhanced phospholipid synthesis in cultured cells, and also suppressed the promoting effect of TPA on skin tumor formation in mice initiated with 7,12-dimethylbenz[a]anthracene. The potency of SDB proved to be stronger than that of other natural antitumor-promoting terpenoids, such as glycyrrhetinic acid.

• Authors: H Nishino, T Hayashi, M Arisawa, Y Satomi, A Iwashima
• Journal: Oncology (Oncology) 1993 Mar-Apr Vol. 50 Issue 2 Pg. 100-3 ISSN: 0030-2414 [Print] Switzerland
• PMID: 8451033 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticarcinogenic Agents
• Diterpenes
• Phospholipids
• scopadulcic acid B
• 9,10-Dimethyl-1,2-benzanthracene
• Tetradecanoylphorbol Acetate

Topics

• 9,10-Dimethyl-1,2-benzanthracene
• Animals
• Anticarcinogenic Agents (therapeutic use)
• Cells, Cultured
• Diterpenes (isolation & purification, therapeutic use)
• Female
• HeLa Cells
• Humans
• Mice
• Mice, Inbred ICR
• Phospholipids (metabolism)
• Plants, Medicinal (chemistry)
• Skin Neoplasms (chemically induced, prevention & control)
• Tetradecanoylphorbol Acetate (pharmacology)