Abstract | BACKGROUND: METHODS: We studied 49 affected and 55 unaffected family members; 52 were adults, and 52 were children. All subjects were evaluated with structured psychiatric questionnaires by interviewers who were unaware of the medical diagnosis. The number of symptoms of attention deficit-hyperactivity disorder was calculated for each subject. RESULTS: Among the adults, 11 of 22 subjects with generalized resistance to thyroid hormone (50 percent) and 2 of 30 unaffected subjects (7 percent) had met the criteria for attention deficit-hyperactivity disorder as children (P < 0.001). Among the children, 19 of 27 subjects resistant to thyroid hormone (70 percent) and 5 of 25 unaffected subjects (20 percent) met the criteria for the disorder (P < 0.001). The odds of having attention deficit-hyperactivity disorder were 3.2 times higher for affected male subjects than for affected female subjects and were 2.7 times higher for unaffected male subjects than for unaffected female subjects. The mean symptom score was 2.5 times higher in the affected group than in the unaffected group (7.0 vs. 2.8, P < 0.001). The frequency of other psychiatric diagnoses was similar in the two groups. CONCLUSIONS:
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Authors | P Hauser, A J Zametkin, P Martinez, B Vitiello, J A Matochik, A J Mixson, B D Weintraub |
Journal | The New England journal of medicine
(N Engl J Med)
Vol. 328
Issue 14
Pg. 997-1001
(Apr 08 1993)
ISSN: 0028-4793 [Print] United States |
PMID | 8450877
(Publication Type: Journal Article)
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Chemical References |
- Receptors, Thyroid Hormone
- Thyroid Hormones
- Triiodothyronine
- Thyrotropin
- Thyroxine
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Topics |
- Adult
- Attention Deficit Disorder with Hyperactivity
(blood, genetics, psychology)
- Child
- Drug Resistance
(genetics)
- Female
- Humans
- Male
- Mental Disorders
(diagnosis)
- Odds Ratio
- Receptors, Thyroid Hormone
(genetics)
- Thyroid Hormones
(blood)
- Thyrotropin
(blood)
- Thyroxine
(blood)
- Triiodothyronine
(blood)
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