Dexfenfluramine in type II diabetes: effect on weight and diabetes control.

Abstract

OBJECTIVE:

To assess the effect of dexfenfluramine on weight loss, diabetic control and blood lipids in type II diabetics over a three-month period.

DESIGN, SETTING AND PATIENTS:

Forty overweight patients in the Diabetic Clinic, Fremantle Hospital, were studied in a double-blind, placebo-controlled trial with a run-in period of one month followed by three months on either dexfenfluramine or placebo.

MAIN OUTCOME MEASURES:

Changes in body weight, and fasting plasma glucose, glycosylated haemoglobin, plasma cholesterol and triglyceride levels.

MAIN RESULTS:

The median change in weight was -3.8 kg in the treatment group (Df) and +0.3 kg in the placebo group (PI) (P = 0.006). The median changes in fasting plasma glucose levels were -1.0 mmol/L (Df) and +0.6 mmol/L (PI) P = 0.010). The median changes in glycosylated haemoglobin levels were -1.4% (Df) and +0.2% (PI) (P = 0.002). The median changes in triglyceride levels were -0.3 mmol/L (Df) and +0.2 mmol/L (PI) (P = 0.017). Cholesterol level did not change significantly.

CONCLUSION:

Dexfenfluramine is effective in achieving weight loss and also improved diabetic control in obese type II diabetics over a three-month period.

• Authors: G O Stewart, G R Stein, T M Davis, P Findlater
• Journal: The Medical journal of Australia (Med J Aust) Vol. 158 Issue 3 Pg. 167-9 (Feb 01 1993) ISSN: 0025-729X [Print] Australia
• PMID: 8450782 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Blood Glucose
• Glycated Hemoglobin A
• Triglycerides
• Fenfluramine
• Cholesterol

Topics

• Adult
• Aged
• Blood Glucose (metabolism)
• Body Weight (drug effects)
• Cholesterol (blood)
• Diabetes Mellitus (drug therapy)
• Diabetes Mellitus, Type 2 (blood, complications, prevention & control)
• Double-Blind Method
• Female
• Fenfluramine (adverse effects, pharmacology, therapeutic use)
• Glycated Hemoglobin (analysis)
• Humans
• Male
• Middle Aged
• Obesity
• Triglycerides (blood)
• Weight Loss (drug effects)