CA 494--a new tumor marker for the diagnosis of pancreatic cancer.

Abstract

In 59 patients with ductal pancreatic cancer the monoclonal antibody (MAb) BW 494, which detects the CA 494 glycoprotein antigen, was analyzed in comparison with the reference tumor markers CA 19-9 and CEA. Eighty-one patients with non-pancreatic malignancies of the gastrointestinal (GI) tract, 95 with chronic pancreatitis, 124 with benign non-pancreatic GI diseases, 30 with diabetes mellitus (type I or type II) and 114 healthy blood donors served as controls. The sensitivity of pancreatic cancer was 90%, 44% and 90% for CA 19-9, CEA and CA 494, respectively. In chronic pancreatitis, as the most important control population for pancreatic cancer, the specificity was 85%, 72% and 94% for CA 19-9, CEA and CA 494, respectively.

• Authors: H Friess, M Büchler, B Auerbach, A Weber, P Malfertheiner, K Hammer, N Madry, S Greiner, K Bosslet, H G Beger
• Journal: International journal of cancer (Int J Cancer) Vol. 53 Issue 5 Pg. 759-63 (Mar 12 1993) ISSN: 0020-7136 [Print] United States
• PMID: 8449599 (Publication Type: Journal Article)

Chemical References

• Antigens, Tumor-Associated, Carbohydrate
• Biomarkers, Tumor
• Carcinoembryonic Antigen

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Antigens, Tumor-Associated, Carbohydrate (blood)
• Biomarkers, Tumor (blood)
• Carcinoembryonic Antigen (blood)
• Diabetes Mellitus (blood)
• Female
• Humans
• Male
• Middle Aged
• Pancreatic Diseases (blood)
• Pancreatic Neoplasms (blood)
• Sensitivity and Specificity