Surfactant improves lung function and morphology in newborn rabbits with meconium aspiration.

Nearly mature newborn rabbits (gestational age 29.5 days) were tracheotomized at birth and received, via the tracheal cannula, 6 ml/kg body weight of a filtered saline suspension of human meconium, 65 or 130 mg/ml. Animals were kept in body plethysmographs and ventilated for 60 min with standardized tidal volume (8-10 ml/kg). Aspiration of meconium caused, in both groups, a statistically significant reduction in lung-thorax compliance, elevated PCO2 in heart blood and reduced alveolar volume density (VV) in histological sections. Both groups responded to treatment with exogenous surfactant (Curosurf, 200 mg/kg) with a moderate, statistically significant improvement in lung-thorax compliance, PCO2 and alveolar VV. Our data indicate that respiratory failure after neonatal meconium aspiration may be influenced favorably by treatment with exogenous surfactant.
AuthorsB Sun, T Curstedt, G W Song, B Robertson
JournalBiology of the neonate (Biol Neonate) Vol. 63 Issue 2 Pg. 96-104 ( 1993) ISSN: 0006-3126 [Print] SWITZERLAND
PMID8448260 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Pulmonary Surfactants
  • Carbon Dioxide
  • Animals
  • Animals, Newborn (physiology)
  • Carbon Dioxide (blood)
  • Humans
  • Infant, Newborn
  • Lung (pathology, physiopathology)
  • Lung Compliance (drug effects)
  • Meconium Aspiration Syndrome (blood, pathology, physiopathology)
  • Partial Pressure
  • Pulmonary Surfactants (pharmacology)
  • Rabbits
  • Swine

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