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Familial cold urticaria. Investigation of a family and response to stanozolol.

AbstractBACKGROUND:
Familial cold urticaria is a rare cutaneous and systemic reaction to cold with autosomal dominant inheritance, distinctive clinical features, and unknown pathogenesis. Release of a chymotrypsinlike substance has been postulated. To date, no effective treatment has been reported.
OBSERVATIONS:
Eight cases from a large family pedigree are described. Three members showed a very favorable response in their cold urticaria, when treated with stanozolol; the response was reproducible. Histologic examination of an early lesion in one case revealed evidence of mast cell degranulation.
CONCLUSIONS:
The biochemical observations are probably secondary epiphenomena. Correction of a deficiency of an inhibitory protein is a possible mechanism of action of stanozolol as in hereditary angioedema.
AuthorsA D Ormerod, L Smart, T M Reid, A Milford-Ward
JournalArchives of dermatology (Arch Dermatol) Vol. 129 Issue 3 Pg. 343-6 (Mar 1993) ISSN: 0003-987X [Print] United States
PMID8447672 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Stanozolol
  • Esterases
Topics
  • Adult
  • Cold Temperature (adverse effects)
  • Esterases (antagonists & inhibitors)
  • Female
  • Humans
  • Middle Aged
  • Pedigree
  • Stanozolol (therapeutic use)
  • Urticaria (blood, drug therapy, etiology, genetics)

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