Abstract | BACKGROUND:
Familial cold urticaria is a rare cutaneous and systemic reaction to cold with autosomal dominant inheritance, distinctive clinical features, and unknown pathogenesis. Release of a chymotrypsinlike substance has been postulated. To date, no effective treatment has been reported. OBSERVATIONS: Eight cases from a large family pedigree are described. Three members showed a very favorable response in their cold urticaria, when treated with stanozolol; the response was reproducible. Histologic examination of an early lesion in one case revealed evidence of mast cell degranulation. CONCLUSIONS: The biochemical observations are probably secondary epiphenomena. Correction of a deficiency of an inhibitory protein is a possible mechanism of action of stanozolol as in hereditary angioedema.
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Authors | A D Ormerod, L Smart, T M Reid, A Milford-Ward |
Journal | Archives of dermatology
(Arch Dermatol)
Vol. 129
Issue 3
Pg. 343-6
(Mar 1993)
ISSN: 0003-987X [Print] United States |
PMID | 8447672
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Adult
- Cold Temperature
(adverse effects)
- Esterases
(antagonists & inhibitors)
- Female
- Humans
- Middle Aged
- Pedigree
- Stanozolol
(therapeutic use)
- Urticaria
(blood, drug therapy, etiology, genetics)
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